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Statin intake and all-cause mortality among older nursing home residents
Background
Statins are progressively accepted as being associated with reduced mortality. However, few real-world statin studies have been conducted on statin use in older people and especially the most frail, that is, the nursing home residents.
Objective
The aim of this study was to evaluate the impact of statin intake in nursing home residents on all-cause mortality.
Method
This is a cross-sectional study of 1,094 older people residing in 6 nursing homes in Flanders (Belgium) between March 1, 2020 and May 30, 2020. We considered all residents who were taking statins for at least 5 days as statin users. All-cause mortality during the 3 months of data collection was the primary outcome. Propensity score overlap-weighted logistic regression models were applied with age, sex, functional status, diabetes, and cardiac failure/ischemia as potential confounders.
Results
185 out of 1,094 residents were on statin therapy (17%). The statin intake was associated with decreased all-cause mortality: 4% absolute risk reduction; adjusted odds ratio 0.50; CI 0.31–0.81, p = 0.005.
Conclusions
The statin intake was associated with decreased all-cause mortality in older people residing in nursing homes. More in-depth studies investigating the potential geroprotector effect of statins in this population are needed.
Authors
A De Spiegeleer, J Van Migerode, A Bronselaer, E Wynendaele, M Peelman, F Vandaele, G Byttebier, G De Tré, L Belmans, C Van De Wiele, M Sathekge, D Van Dijck, B Saxberg, M Alexander, D Fedson, D Elewaut, N Van Den Noortgate B De Spiegeleer
Journal
Gerontology
Therapeutic Area
Cardiology
Center of Excellence
Real-world Evidence & Data Analytics
Year
2021
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