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Priority acute and preventive migraine treatment benefits: Results of the Migraine Clinical Outcome Assessment System (MiCOAS) qualitative study of people living with migraine
Background
There is renewed emphasis on including patients in determining, defining, and prioritizing outcomes for migraine treatment.
Objectives
To obtain insights directly from people living with migraine on their priorities for treatment.
Methods
In partnership with Vector Psychometric Group and the Coalition for Headache and Migraine Patients (CHAMP), a total of 40 qualitative interviews were conducted by OPEN Health researchers as part of the Migraine Clinical Outcome Assessment System project, a United States Food and Drug Administration grant-funded program to develop a core set of patient-centered outcome measures for migraine clinical trials. Interviews included a structured exercise in which participants rank-ordered pre-defined lists of potential benefits for acute and preventive migraine therapy. The 40 study participants who reported being diagnosed with migraine by a clinician ranked the benefits and explained their rationale.
Results
Study participants consistently ranked either pain relief or absence of pain as their top priority for acute treatment. Relief/absence of other migraine symptoms and improved functioning were also prioritized. For preventive treatment, participants prioritized reductions in migraine frequency, symptom severity, and attack duration. Few differences were found between participants with episodic migraine and those with chronic migraine. However, participants with chronic migraine ranked “increased predictability of attacks” much higher than those with episodic migraine. Participants’ rankings were influenced by prior expectations and experiences of migraine treatments, which caused many participants to deprioritize desired benefits as unrealistic. Participants also identified several additional priorities, including limited side-effects and reliable treatment efficacy in both acute and preventive treatments.
Conclusion
The results showed the participants prioritized treatment benefits aligned with existing core clinical outcomes used in migraine research, but also valued benefits that are not typically assessed, such as predictability. Participants also deprioritized important benefits when they believed treatment was unlikely to deliver those outcomes.
Authors
R Mangrum, M T Gerstein, C J Hall, D C Buse, C R Houts, J S McGinley, K P McCarrier, R B Lipton, R J Wirth
Journal
Headache: The Journal of Head and Face Pain
Therapeutic Area
Neurology
Center of Excellence
Patient-Centered outcomes
Year
2023
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