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Key considerations for the collection of patient reported outcome (PRO) data in real world (RW) studies
Background
The collection of patient reported outcome (PRO) data in the real world (RW) is of growing importance to key patient and industry stakeholders who attribute value to data collected from patients outside of highly selected clinical trial populations, in observational, and often more clinically realistic populations. Regulatory authority guidelines informing researchers on the design and conduct of PRO assessment (e.g. FDA PRO guidelines) focus on randomised clinical trials and the recommendations are not always proportionate to RW study settings.
Aim
This work aims to summarise the key considerations for researchers collecting PRO data in RW studies. KEY CONSIDERATIONS include; a.) Study design: the choice of a retrospective or prospective design, and potentially the amount of missing data, will be influenced by whether PRO data are routinely collected in clinical practice; b.) Patient recruitment: the level of contact patients have with healthcare services will impact recruitment methodologies and may affect levels of patient engagement with the study; c.) Data collection: RW studies cannot influence the scheduling of clinic visits which is likely to impact the timing and method of PRO measurement; d.) Minimisation of patient burden: the frequency of PRO measurement and subsequent follow-up must be limited to the necessary minimum in RW studies so as not to impact routine clinical care
Conclusions
Whilst authors of the International Society for Quality of Life Research (ISOQOL) have published a User’s Guide for Implementing PROs Assessment in Clinical Practice, there are no specific guidelines for optimising the design and conduct of patient centred research studies in RW settings. We propose that a specific set of guidelines should be developed.
Authors
AJ Rylands, E Boxell, C Bottomley
Journal
Value in health
Center of Excellence
Patient-Centered outcomes
Year
2018
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