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A psychometric analysis and revalidation of the Yale-Brown Obsessive Compulsive Scale modified for binge eating in adults with binge eating disorder
Purpose
The Yale-Brown Obsessive Compulsive Scale modified for Binge Eating (Y-BOCS-BE) assesses the obsessiveness of binge eating thoughts and compulsiveness of binge eating behaviors. The findings of this study extend previously published Y-BOCS-BE psychometric evaluations in adults with binge eating disorder (BED).
Methods
Data from three phase 3 lisdexamfetamine dimesylate studies in adults with BED (two randomized, double-blind, placebo-controlled short-term efficacy studies; one double-blind, placebo-controlled, randomized-withdrawal maintenance-of-efficacy study) were used. Psychometric evaluations included assessment of Y-BOCS-BE dimensionality, internal consistency, convergent validity, test-retest reliability, and determinations of clinically meaningful improvement using distribution- and anchor-based methods.
Results
Domain specification analyses determined that the Y-BOCS-BE possessed a bifactor structure composed of a general binge eating severity domain and three subdomains (obsessive/compulsive, restraint, and control). Y-BOCS-BE internal consistency was maximized at week 12 (Cronbach’s α, 0.95) and test-retest reliability was maximized in the 8-week retest interval from week 4 to week 12 across all no-change anchors (r = 0.74-0.90). Likewise, convergent validity of the Y-BOCS-BE across all validators was maximized at week 12 (all r ≥ 0.66). Meaningful improvement for Y-BOCS-BE total scores was estimated to require score reductions of 12 to 17 points depending on the anchor.
Conclusions
The Y-BOCS-BE is a valuable tool for assessing BED symptoms. Maximization of Y-BOCS-BE reliability and validity at later study time points may be related to both treatment effects and improved insight into BED by participants during the study.
Authors
K Yee, D Serrano, J Kando, S L McElroy
Journal
Quality of life research
Therapeutic Area
Other
Center of Excellence
Patient-Centered outcomes
Year
2019
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